Not knees, but hands.......I had taken generic glucosamine condrointin before and had no relief at all.....a waste of money. Earlier this summer on the suggestion of a relative, tried the brand name Osteo-BiFlex, and lo and behold, it either really helped, or the situation cycled for the better coincidentally. Guess I can't really state without a doubt that it was the BiFlex, but within about 2 weeks of starting it, the issue with my hands/thumbs really improved. Might be worth a try for you. Aleve helps also, but I know some folks have trouble taking that. Good luck!