Can't speak to the specific mouse issue, but have experienced one of those generators in a house that was smoked in .........veryveryvery heavily.....for more than 40 years. I'm talking 2 people, 2-pack-a-day each heavily. 24hours with a rental ozone machine, and you absolutely could not tell there had ever been a cigarette in that house, except by the discoloration in the furniture. And I consider myself overly sensitive to that odor. It was amazing. I'd think it would take care of your mousey issue pretty easily.