Posted 2/23/2013 20:09 (#2921179 - in reply to #2920970) Subject: A truck frame for example.
Always drill and fasten to the web, never the flanges. And, make sure all un-used holes are filled with the proper size bolt, even if it means drilling a larger hole to use the proper fitting bolt.
So if you would have taken a 10x12 or so and carved the I that met the same dimensions as your 2x6 I, you'd be ok?