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Tipton, KS | Implantable 'cell factories' produce drugs inside the body
Tiny devices containing cells engineered to continuously produce drugs could one day deliver medicines from inside the body without requiring patients to remember to administer doses.
Researchers have designed a device called hybrid oxygenation bioelectronics system for implanted therapy, or HOBIT, in a step towards realising this goal.
The system hides genetically-engineered cells from the immune system while producing its own oxygen and nutrients to keep the cells alive.
In a proof-of-concept study the team engineered cells to produce an anti-HIV antibody, a GLP-1-like peptide used to treat type 2 diabetes and leptin, a hormone that regulates appetite and metabolism. They implanted the devices under the skin of rats and monitored drug levels in the animals’ bloodstreams for 30 days.
https://connectsci.au/news/news-parent/8108/Implantable-cell-factori...
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Implantable 'cell factories'
