Tipton, KS | John Burns - 3/3/2026 02:42
pharma companies
The Lipid Hypothesis has been debated for over 150 years. "Cholesterol was first discovered in bile and in the gallstones by Poulletier de la Salle in 1769 and rediscovered by Michel Eugene Chevreul in 1815. The latter coined the name “cholesterine” which was shown to be present in bilestones."
"During the 1990s, clinical trials with statins, beginning with the 4S study with simvastatin, provided the evidence needed to confirm the lipid hypothesis and silence the skeptics. Numerous trials were held – showing statin efficacy in men, women, the elderly, and patients with diabetes. By 2012, the evidence base had accumulated to the extent that a meta-analysis, published by Cholesterol Treatment Trialists, published pool data from 170,000 participants in 12 randomized trials. This study showed that, for every 39 mg/dL reduction in LDL-C, the risk for major vascular events is reduced by one-fifth, with no apparent lower threshold beyond which LDL-C ceases to be beneficial. After years of controversy, the lipid hypothesis was confirmed"
https://www.lipid.org/lipid-spin/summer-2022/lipid-hypothesis |
Lowering LDL without statins
