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EC Nebraska | One side note to remember is that gluconeogenesis is a pretty energy-expensive process. Or you could say energy-inefficient. The amount of useable energy in the resulting glucose is much less than the energy originally contained in the fat or protein that went into the process.
It's been twenty years since I took biochem, but there are at least three, maybe four, rate-limiting steps in that pathway. Negative feed-back at any one of them will stop the whole thing, and normal levels of blood glucose exert negative feedback.
Anything is possible, but a lot of things would have go wrong before gluconeogenesis would "run away" producing excess glucose. | |
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Exogenous ketones
